MolNFT v1 · #118308 · protein
Crystal structure of cody from staphylococcus aureus with GTP and ile
5EY0 · GTP-sensing transcriptional pleiotropic repressor cody: “Crystal structure of cody from staphylococcus aureus with GTP and ile”. X-ray diffraction, 2 ligands (ILE, GTP), 8 pockets (best druggability 0.56). MolNFT v1 #118308 on…
- PDB
- 5EY0
- Type
- protein
- Length
- 505 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP-sensing transcriptional pleiotropic repressor cody
- UniProt
- A7X1N2
- Ligands
- ILE, GTP
- Pockets
- 8 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | GTP-sensing transcriptional pleiotropic repressor cody | protein | 253 | 54% helix, 19% strand | A7X1N2 |
| A | GTP-sensing transcriptional pleiotropic repressor cody | protein | 252 | 51% helix, 19% strand | A7X1N2 |
Ligands and binding sites
- ILE · Isoleucine · ligand · 2 copies · chains B, A
- GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 309 | 0.56 | 0.76 | 40 | empty |
| 2 | 83 | 0.49 | 0.83 | 18 | ILE |
| 3 | 83 | 0.47 | 0.81 | 15 | ILE |
| 4 | 65 | 0.38 | 0.79 | 14 | empty |
| 5 | 80 | 0.36 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- B–A · 1684 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 5EY0 · Crystal structure of CodY from Staphylococcus aureus with GTP and Ile · the same entry in another collection · chain A against A, TM-score 1.00
- A7X1N2 · AlphaFold monomer V2.0 prediction for GTP-sensing transcriptional pleiotropic repressor… · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A7X1N2
- Elsewhere: RCSB PDB 5EY0 · PDBe 5EY0 · UniProt A7X1N2
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