MolNFT v1 · #118157 · protein
Structure of dead kinase MAPK14
5ETI · Mitogen-activated protein kinase 14: “Structure of dead kinase MAPK14”. X-ray diffraction, 5 pockets (best druggability 0.62). MolNFT v1 #118157 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ETI
- Type
- protein
- Length
- 355 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 14
- EC
- 2.7.11.24
- UniProt
- Q16539
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 14 (EC 2.7.11.24) | protein | 355 | 41% helix, 14% strand | Q16539 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.62 | 0.88 | 18 | empty |
| 2 | 321 | 0.60 | 0.78 | 35 | empty |
| 3 | 203 | 0.54 | 0.78 | 22 | empty |
| 4 | 54 | 0.33 | 0.78 | 15 | empty |
| 5 | 59 | 0.29 | 0.74 | 15 | empty |
Compared structures
- 5ETI · Structure of dead kinase MAPK14 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16539
- Elsewhere: RCSB PDB 5ETI · PDBe 5ETI · UniProt Q16539
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