MolNFT v1 · #11797 · protein

I53A, a point mutant of the cysteine-free variant of E. COLI RNase hi

1JXB · Ribonuclease hi: “I53A, a point mutant of the cysteine-free variant of E. COLI RNase hi”. X-ray diffraction, 2 pockets (best druggability 0.29). MolNFT v1 #11797 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1JXB
Type: protein
Length: 152 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease hi
EC: 3.1.26.4
UniProt: P0A7Y4
Pockets: 2 · best druggability 0.29

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribonuclease hi (EC 3.1.26.4)	protein	152	37% helix, 31% strand	P0A7Y4

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.29	0.75	16	empty
2	54	0.27	0.73	16	empty

Compared structures

1JXB · I53A, a point mutant of the cysteine-free variant of E. coli Rnase HI · the same entry in another collection · chain A against A, TM-score 1.00
P0A7Y4 · AlphaFold monomer V2.0 prediction for ribonuclease hi (P0A7Y4) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A7Y4
Elsewhere: RCSB PDB 1JXB · PDBe 1JXB · UniProt P0A7Y4

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