UniProt P0A7Y4
Ribonuclease HI (P0A7Y4)
Ribonuclease HI (UniProt P0A7Y4), EC 3.1.26.4: 94 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A7Y4
- Protein
- Ribonuclease HI
- EC
- 3.1.26.4
- Experimental structures
- 94
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 10 · 4 records with a druggable one
Structures
95 records of P0A7Y4 in the MolNFT archive: 94 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F21 | Divalent metal cofactor binding in the kinetic folding trajectory of E. COLI ribonuclease hi | x-ray diffraction | A | — | — |
| 1F21 | Divalent metal cofactor binding in the kinetic folding trajectory of E. COLI ribonuclease hi | x-ray diffraction | A | — | — |
| 1G15 | Co-crystal of E. COLI RNase hi with two MN2+ ions bound in the the active site | x-ray diffraction | A | — | — |
| 1G15 | Co-crystal of E. COLI RNase hi with two MN2+ ions bound in the the active site | x-ray diffraction | A | — | — |
| 1GOA | Cooperative stabilization of escherichia COLI ribonuclease hi by insertion of gly-80B and gly-77->… | x-ray diffraction | A | — | — |
| 1GOA | Cooperative stabilization of escherichia COLI ribonuclease hi by insertion of gly-80B and gly-77->… | x-ray diffraction | A | — | — |
| 1GOB | Cooperative stabilization of escherichia COLI ribonuclease hi by insertion of gly-80B and gly-77->… | x-ray diffraction | A | — | — |
| 1GOB | Cooperative stabilization of escherichia COLI ribonuclease hi by insertion of gly-80B and gly-77->… | x-ray diffraction | A | — | — |
| 1GOC | Cooperative stabilization of escherichia COLI ribonuclease hi by insertion of gly-80B and gly-77->… | x-ray diffraction | A | — | — |
| 1GOC | Cooperative stabilization of escherichia COLI ribonuclease hi by insertion of gly-80B and gly-77->… | x-ray diffraction | A | — | — |
| 1JL1 | D10A E. coli ribonuclease HI | x-ray diffraction | A | — | — |
| 1JL1 | D10A E. COLI ribonuclease hi | x-ray diffraction | A | — | — |
| 1JL2 | Crystal structure of TCEO RNase H-a chimera combining the folding core from T. thermophilus RNase H… | x-ray diffraction | A, B, C, D | — | — |
| 1JL2 | Crystal structure of tceo RNase H-a chimera combining the folding core from T. thermophilus RNase H… | x-ray diffraction | A, B, C, D | — | — |
| 1JXB | I53A, a point mutant of the cysteine-free variant of E. coli Rnase HI | x-ray diffraction | A | — | — |
| 1JXB | I53A, a point mutant of the cysteine-free variant of E. COLI RNase hi | x-ray diffraction | A | — | — |
| 1KVA | E. COLI ribonuclease hi D134A mutant | x-ray diffraction | A | — | — |
| 1KVA | E. COLI ribonuclease hi D134A mutant | x-ray diffraction | A | — | — |
| 1KVB | E. COLI ribonuclease hi D134H mutant | x-ray diffraction | A | — | — |
| 1KVB | E. COLI ribonuclease hi D134H mutant | x-ray diffraction | A | — | — |
| 1KVC | E. COLI ribonuclease hi D134N mutant | x-ray diffraction | A | — | — |
| 1KVC | E. COLI ribonuclease hi D134N mutant | x-ray diffraction | A | — | — |
| 1LAV | Stabilization of escherichia COLI ribonuclease hi by cavity-filling mutations within a hydrophobic… | x-ray diffraction | A | — | — |
| 1LAV | Stabilization of escherichia COLI ribonuclease hi by cavity-filling mutations within a hydrophobic… | x-ray diffraction | A | — | — |
| 1LAW | Stabilization of escherichia COLI ribonuclease hi by cavity-filling mutations within a hydrophobic… | x-ray diffraction | A | — | — |
| 1LAW | Stabilization of escherichia COLI ribonuclease hi by cavity-filling mutations within a hydrophobic… | x-ray diffraction | A | — | — |
| 1RBR | Structural study of mutants of escherichia COLI ribonuclease hi with enhanced thermostability | x-ray diffraction | A | — | — |
| 1RBR | Structural study of mutants of escherichia COLI ribonuclease hi with enhanced thermostability | x-ray diffraction | A | — | — |
| 1RBS | Structural study of mutants of escherichia COLI ribonuclease hi with enhanced thermostability | x-ray diffraction | A | — | — |
| 1RBS | Structural study of mutants of escherichia COLI ribonuclease hi with enhanced thermostability | x-ray diffraction | A | — | — |
| 1RBT | Structural study of mutants of escherichia COLI ribonuclease hi with enhanced thermostability | x-ray diffraction | A | — | — |
| 1RBT | Structural study of mutants of escherichia COLI ribonuclease hi with enhanced thermostability | x-ray diffraction | A | — | — |
| 1RBU | Structural study of mutants of escherichia COLI ribonuclease hi with enhanced thermostability | x-ray diffraction | A | — | — |
| 1RBU | Structural study of mutants of escherichia COLI ribonuclease hi with enhanced thermostability | x-ray diffraction | A | — | — |
| 1RBV | Structural study of mutants of escherichia COLI ribonuclease hi with enhanced thermostability | x-ray diffraction | A | — | — |
| 1RBV | Structural study of mutants of escherichia COLI ribonuclease hi with enhanced thermostability | x-ray diffraction | A | — | — |
| 1RCH | Solution NMR structure of ribonuclease hi from escherichia COLI, 8 structures | solution nmr | A | — | — |
| 1RCH | Solution NMR structure of ribonuclease hi from escherichia COLI, 8 structures | solution nmr | A | — | — |
| 1RDA | Crystal structures of ribonuclease hi active site mutants from escherichia COLI | x-ray diffraction | A | — | — |
| 1RDA | Crystal structures of ribonuclease hi active site mutants from escherichia COLI | x-ray diffraction | A | — | — |
| 1RDB | Crystal structures of ribonuclease hi active site mutants from escherichia COLI | x-ray diffraction | A | — | — |
| 1RDB | Crystal structures of ribonuclease hi active site mutants from escherichia COLI | x-ray diffraction | A | — | — |
| 1RDC | Crystal structures of ribonuclease hi active site mutants from escherichia COLI | x-ray diffraction | A | — | — |
| 1RDC | Crystal structures of ribonuclease hi active site mutants from escherichia COLI | x-ray diffraction | A | — | — |
| 1RDD | Crystal structure of escherichia COLI RNase hi in complex with MG2+ at 2.8 ångströms resolution… | x-ray diffraction | A | — | — |
| 1RDD | Crystal structure of escherichia COLI RNase hi in complex with MG2+ at 2.8 ångströms resolution… | x-ray diffraction | A | — | — |
| 1WSE | Co-crystal structure of E.coli RNase HI active site mutant (E48A*) with Mn2+ | x-ray diffraction | A, B | — | — |
| 1WSE | Co-crystal structure of E.COLI RNase hi active site mutant (E48A*) with MN2+ | x-ray diffraction | A, B | — | — |
| 1WSF | Co-crystal structure of E.coli RNase HI active site mutant (D134A*) with Mn2+ | x-ray diffraction | A, B, C, D | — | — |
| 1WSF | Co-crystal structure of E.COLI RNase hi active site mutant (D134A*) with MN2+ | x-ray diffraction | A, B, C, D | — | — |
| 1WSG | Co-crystal structure of E.coli RNase HI active site mutant (E48A/D134N*) with Mn2+ | x-ray diffraction | A, B, C, D | — | — |
| 1WSG | Co-crystal structure of E.COLI RNase hi active site mutant (E48A/D134N*) with MN2+ | x-ray diffraction | A, B, C, D | — | — |
| 1WSH | Crystal structure of E.coli RNase HI active site mutant (E48A/K87A) | x-ray diffraction | A, B, C, D | — | — |
| 1WSH | Crystal structure of E.COLI RNase hi active site mutant (E48A/K87A) | x-ray diffraction | A, B, C, D | — | — |
| 1WSI | Crystal structure of E.coli RNase HI active site mutant (E48A/K87A/D134N) | x-ray diffraction | A, B, C, D | — | — |
| 1WSI | Crystal structure of E.COLI RNase hi active site mutant (E48A/K87A/D134N) | x-ray diffraction | A, B, C, D | — | — |
| 1WSJ | Crystal structure of E.coli RNase HI active site mutant (K87A/H124A) | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1WSJ | Crystal structure of E.COLI RNase hi active site mutant (K87A/H124A) | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2RN2 | Structural details of ribonuclease H from escherichia COLI as refined to an atomic resolution | x-ray diffraction | A | — | — |
| 2RN2 | Structural details of ribonuclease H from escherichia COLI as refined to an atomic resolution | x-ray diffraction | A | — | — |
35 records more on the page itself.
Ligands
Experiment against prediction
- 1WSJ chain C against the predicted model P0A7Y4: TM-score 0.99, RMSD 0.52 Å
- 1WSJ chain C against the predicted model P0A7Y4: TM-score 0.99, RMSD 0.52 Å
- 1WSJ chain H against the predicted model P0A7Y4: TM-score 0.99, RMSD 0.66 Å
- 3AA2 chain A against the predicted model P0A7Y4: TM-score 0.98, RMSD 0.72 Å
- 1JXB chain A against the predicted model P0A7Y4: TM-score 0.98, RMSD 0.65 Å
- 1JXB chain A against the predicted model P0A7Y4: TM-score 0.98, RMSD 0.65 Å
- 3AA4 chain A against the predicted model P0A7Y4: TM-score 0.98, RMSD 0.62 Å
- 1WSH chain C against the predicted model P0A7Y4: TM-score 0.98, RMSD 0.62 Å
- 1WSH chain C against the predicted model P0A7Y4: TM-score 0.98, RMSD 0.62 Å
- 1F21 chain A against the predicted model P0A7Y4: TM-score 0.98, RMSD 0.67 Å
Elsewhere
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