MolNFT v1 · #117928 · protein
Crystal structure of the palmitoylated human TEAD2 transcription factor
5EMV · Transcriptional enhancer factor tef-4: “Crystal structure of the palmitoylated human TEAD2 transcription factor”. X-ray diffraction, 3 pockets (best druggability 0.65). MolNFT v1 #117928 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5EMV
- Type
- protein
- Length
- 398 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional enhancer factor tef-4
- UniProt
- Q15562
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 19% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional enhancer factor tef-4 | protein | 194 | 18% helix, 53% strand | Q15562 |
| B | Transcriptional enhancer factor tef-4 | protein | 204 | 20% helix, 50% strand | Q15562 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 384 | 0.65 | 0.79 | 39 | empty |
| 2 | 440 | 0.57 | 0.74 | 47 | empty |
| 3 | 82 | 0.34 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 546 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (nonstandard).
Compared structures
- 5EMV · Crystal structure of the palmitoylated human TEAD2 transcription factor · the same entry in another collection · chain A against A, TM-score 1.00
- Q15562 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-4 (Q15562) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15562
- Elsewhere: RCSB PDB 5EMV · PDBe 5EMV · UniProt Q15562
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