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MolNFT v1 · #117890 · protein + RNA

Structure of the kh-QUA2 domain of T-star in complex with aauaau RNA

5ELR · RNA (5'-R(*AP*AP*UP*AP*AP*U)-3'): “Structure of the kh-QUA2 domain of T-star in complex with aauaau RNA”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #117890 on GenesisL1: 3D structure, binding sites and pockets…

PDB
5ELR
Type
protein + RNA
Length
230 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
RNA (5'-R(*AP*AP*UP*AP*AP*U)-3'); Kh domain-containing, RNA-binding, signal transduction…
UniProt
O75525
Pockets
1 · best druggability 0.30

Structure

x-ray diffraction · 3 distinct chains · 45% helix, 19% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
BRNA (5'-R(*AP*AP*UP*AP*AP*U)-3')rna5——
CKh domain-containing, RNA-binding, signal transduction- associated protein 3protein11146% helix, 19% strandO75525
DKh domain-containing, RNA-binding, signal transduction- associated protein 3protein11444% helix, 18% strandO75525

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1620.300.7515empty

Interfaces

2 interfaces between chains.

  • C–D · 760 Ų buried · 5 hydrogen bonds · protein-protein
  • B–C · 646 Ų buried · 12 hydrogen bonds · protein-nucleic

Compared structures

  • 5ELR · Structure of the KH-QUA2 domain of T-STAR in complex with AAUAAU RNA · the same entry in another collection · chain B against B, TM-score 1.00
  • O75525 · AlphaFold monomer V2.0 prediction for kh domain-containing, RNA- binding, signal… · a predicted model of the same protein · chain C against A, TM-score 0.98

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