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Structure of the kh-QUA2 domain of T-star in complex with aauaau RNA

Analyse Structure of the kh-QUA2 domain of T-star in complex with aauaau RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5ELR
Type: protein + RNA
Length: 230 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (5'-R(*AP*AP*UP*AP*AP*U)-3'); Kh domain-containing, RNA-binding, signal transduction…
UniProt: O75525
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 3 distinct chains · 45% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	RNA (5'-R(APAPUPAPAPU)-3')	rna	5	—	—
C	Kh domain-containing, RNA-binding, signal transduction- associated protein 3	protein	111	46% helix, 19% strand	O75525
D	Kh domain-containing, RNA-binding, signal transduction- associated protein 3	protein	114	44% helix, 18% strand	O75525

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.30	0.75	15	empty

Interfaces

2 interfaces between chains.

C–D · 760 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 646 Å² buried · 12 hydrogen bonds · protein-nucleic

Compared structures

5ELR · Structure of the KH-QUA2 domain of T-STAR in complex with AAUAAU RNA · the same entry in another collection · chain B against B, TM-score 1.00
O75525 · AlphaFold monomer V2.0 prediction for kh domain-containing, RNA- binding, signal… · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75525
Elsewhere: RCSB PDB 5ELR · PDBe 5ELR · UniProt O75525

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