MolNFT v1 · #117757 · protein
Sfgfp mutant with unnatural amino acid 4-azidoethoxy-L-phenylalanine incorporated at the 149 site
5EHU · Green fluorescent protein: “Sfgfp mutant with unnatural amino acid 4-azidoethoxy-L-phenylalanine incorporated at the 149 site”. X-ray diffraction, 1 ligand (CRO), 3 pockets (best druggability 0.76). MolNFT v1 #117757 on GenesisL1…
- PDB
- 5EHU
- Type
- protein
- Length
- 456 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Green fluorescent protein
- UniProt
- A0A059PIQ0
- Ligands
- CRO
- Pockets
- 3 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 12% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Green fluorescent protein | protein | 228 | 12% helix, 50% strand | A0A059PIQ0 |
Ligands and binding sites
- CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.76 | 0.97 | 25 | CRO |
| 2 | 91 | 0.76 | 0.97 | 24 | CRO |
| 3 | 165 | 0.46 | 0.76 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 227 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 cofactor, 2 modified (chromophore, nonstandard).
Compared structures
- 5EHU · sfGFP mutant with unnatural amino acid 4-azidoethoxy-L-phenylalanine incorporated at the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A059PIQ0
- Elsewhere: RCSB PDB 5EHU · PDBe 5EHU · UniProt A0A059PIQ0
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