MolNFT v1 · #117609 · protein
Human FABP4 in complex with 6-chloro-4-phenyl-2-piperidin-1-yl- quinoline-3-carboxylic acid at 1.29A
5EDC · Fatty acid-binding protein, adipocyte: “Human FABP4 in complex with 6-chloro-4-phenyl-2-piperidin-1-yl- quinoline-3-carboxylic acid at 1.29A”. X-ray diffraction, 2 ligands (5M7, SO4), 1 pocket (best druggability 0.85). MolNFT v1…
- PDB
- 5EDC
- Type
- protein
- Length
- 133 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fatty acid-binding protein, adipocyte
- UniProt
- P15090
- Ligands
- 5M7, SO4
- Pockets
- 1 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 17% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fatty acid-binding protein, adipocyte | protein | 133 | 17% helix, 57% strand | P15090 |
Ligands and binding sites
- 5M7 · 6-chloranyl-4-phenyl-2-piperidin-1-yl-quinoline-3-carboxylic acid · ligand · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 300 | 0.85 | 0.95 | 34 | 5M7 |
Compared structures
- 5EDC · human FABP4 in complex with 6-Chloro-4-phenyl-2-piperidin-1-yl-quinoline-3-carboxylic… · the same entry in another collection · chain A against A, TM-score 1.00
- P15090 · AlphaFold monomer V2.0 prediction for fatty acid-binding protein, adipocyte (P15090) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15090
- Elsewhere: RCSB PDB 5EDC · PDBe 5EDC · UniProt P15090
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