MolNFT v1 · #117509 · protein

Crystal structure of prefusion rsv F glycoprotein fusion inhibitor resistance mutant D489Y

5EA8 · Fusion glycoprotein F0: “Crystal structure of prefusion rsv F glycoprotein fusion inhibitor resistance mutant D489Y”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.41). MolNFT v1 #117509 on GenesisL1: 3D…

PDB: 5EA8
Type: protein
Length: 448 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fusion glycoprotein F0
UniProt: P03420
Ligands: SO4
Pockets: 1 · best druggability 0.41

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
F	Fusion glycoprotein F0	protein	448	30% helix, 33% strand	P03420

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains F
NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · chains F
TAR · D(-)-tartaric acid · additive · chains F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	150	0.41	0.74	24	empty

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

5EA8 · Crystal Structure of Prefusion RSV F Glycoprotein Fusion Inhibitor Resistance Mutant D489Y · the same entry in another collection · chain F against F, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03420
Elsewhere: RCSB PDB 5EA8 · PDBe 5EA8 · UniProt P03420

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