MolNFT v1 · #117190 · protein

Human PCNA mutant - S228I

5E0T · Proliferating cell nuclear antigen: “Human PCNA mutant - S228I”. X-ray diffraction, 5 pockets (best druggability 0.44). MolNFT v1 #117190 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5E0T
Type: protein
Length: 753 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proliferating cell nuclear antigen
UniProt: P12004
Pockets: 5 · best druggability 0.44

Structure

x-ray diffraction · 3 distinct chains · 19% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proliferating cell nuclear antigen	protein	248	19% helix, 47% strand	P12004
B	Proliferating cell nuclear antigen	protein	253	20% helix, 47% strand	P12004
C	Proliferating cell nuclear antigen	protein	252	19% helix, 46% strand	P12004

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	136	0.44	0.76	19	empty
2	75	0.39	0.78	17	empty
3	89	0.38	0.77	20	empty
4	70	0.31	0.75	22	empty
5	67	0.31	0.75	20	empty

Interfaces

3 interfaces between chains.

B–C · 760 Å² buried · 15 hydrogen bonds · protein-protein
A–C · 758 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 757 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

5E0T · Human PCNA mutant - S228I · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12004
Elsewhere: RCSB PDB 5E0T · PDBe 5E0T · UniProt P12004

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