MolNFT v1 · #116982 · protein + DNA
Identification of a new FOXO1 binding site that precludes creb binding at the glucose-6-phosphatase catalytic subunit gene promoter
5DUI · Forkhead box protein O1: “Identification of a new FOXO1 binding site that precludes creb binding at the glucose-6-phosphatase catalytic…”. X-ray diffraction, 4 pockets (best druggability 0.31). MolNFT v1 #116982 on GenesisL1: 3D…
- PDB
- 5DUI
- Type
- protein + DNA
- Length
- 213 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Forkhead box protein O1; DNA (5'- D(*TP*TP*TP*TP*CP*TP*AP*TP*TP*TP*TP*AP*CP*GP*TP*AP*AP*AP…
- UniProt
- Q12778
- Pockets
- 4 · best druggability 0.31
Structure
x-ray diffraction · 4 distinct chains · 40% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Forkhead box protein O1 | protein | 86 | 43% helix, 12% strand | Q12778 |
| B | Forkhead box protein O1 | protein | 85 | 36% helix, 12% strand | Q12778 |
| C | DNA (5'- D(*TP*TP*TP*TP*CP*TP*AP*TP*TP*TP*TP*AP*CP*GP*TP*AP*AP*AP*TP*CP*A)- 3') | dna | 21 | — | — |
| D | DNA (5'- D(*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*TP*AP*AP*AP*AP*TP*AP*GP*AP*AP*A)- 3') | dna | 21 | — | — |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.31 | 0.75 | 13 | empty |
| 2 | 60 | 0.30 | 0.76 | 11 | empty |
| 3 | 57 | 0.30 | 0.75 | 11 | empty |
| 4 | 58 | 0.26 | 0.73 | 12 | empty |
Interfaces
5 interfaces between chains.
- C–D · 888 Ų buried · 71 hydrogen bonds · nucleic-nucleic
- A–D · 523 Ų buried · 8 hydrogen bonds · protein-nucleic
- A–C · 341 Ų buried · 6 hydrogen bonds · protein-nucleic
- B–D · 247 Ų buried · 4 hydrogen bonds · protein-nucleic
- B–C · 118 Ų buried · 2 hydrogen bonds · protein-nucleic
Compared structures
- 5DUI · Identification of a new FoxO1 binding site that precludes CREB binding at the… · the same entry in another collection · chain A against A, TM-score 1.00
- Q12778 · AlphaFold monomer V2.0 prediction for forkhead box protein O1 (Q12778) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12778
- Elsewhere: RCSB PDB 5DUI · PDBe 5DUI · UniProt Q12778
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