MolNFT v1 · #116967 · protein
Active form of human C1-inhibitor
5DU3 · Plasma protease C1 inhibitor: “Active form of human C1-inhibitor”. X-ray diffraction, 10 pockets (best druggability 0.77). MolNFT v1 #116967 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5DU3
- Type
- protein
- Length
- 755 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Plasma protease C1 inhibitor
- UniProt
- P05155
- Pockets
- 10 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Plasma protease C1 inhibitor | protein | 378 | 30% helix, 31% strand | P05155 |
| B | Plasma protease C1 inhibitor | protein | 377 | 30% helix, 31% strand | P05155 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 865 | 0.77 | 0.80 | 80 | empty |
| 2 | 367 | 0.69 | 0.82 | 47 | empty |
| 3 | 135 | 0.60 | 0.85 | 31 | empty |
| 4 | 153 | 0.55 | 0.81 | 23 | empty |
| 5 | 143 | 0.53 | 0.81 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 717 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05155
- Elsewhere: RCSB PDB 5DU3 · PDBe 5DU3 · UniProt P05155
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