UniProt P05155
Plasma protease C1 inhibitor (P05155)
Plasma protease C1 inhibitor (UniProt P05155): 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05155
- Protein
- Plasma protease C1 inhibitor
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 25 · 4 records with a druggable one
Structures
10 records of P05155 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2OAY | Crystal structure of latent human C1-inhibitor | x-ray diffraction | A | — | — |
| 2OAY | Crystal structure of latent human C1-inhibitor | x-ray diffraction | A | — | — |
| 5DU3 | Active form of human C1-inhibitor | x-ray diffraction | A, B | — | 10 (best 0.77) |
| 5DU3 | Active form of human C1-inhibitor | x-ray diffraction | A, B | — | — |
| 5DUQ | Active human c1-inhibitor in complex with dextran sulfate | x-ray diffraction | A, B | NAG, GLC, SO3 | — |
| 5DUQ | Active human C1-inhibitor in complex with dextran sulfate | x-ray diffraction | A, B | — | — |
| 7AKV | The cryo-EM structure of the Vag8-C1 inhibitor complex | electron microscopy | A | — | 5 (best 0.78) |
| 7AKV | The cryo-EM structure of the VAG8-C1 inhibitor complex | electron microscopy | A | — | — |
| 8W18 | The crystal structure of the Michaelis-Menten complex of a C1s/C1-INH at 3.94 Angstroms | x-ray diffraction | I | — | 6 (best 0.75) |
| P05155 | AlphaFold monomer V2.0 prediction for plasma protease C1 inhibitor (P05155) | predicted | A | — | 4 (best 0.58) |
Ligands
Experiment against prediction
- 5DU3 chain A against the predicted model P05155: TM-score 1.00, RMSD 0.51 Å
- 5DU3 chain A against the predicted model P05155: TM-score 1.00, RMSD 0.51 Å
- 5DU3 chain B against the predicted model P05155: TM-score 0.99, RMSD 0.61 Å
- 5DU3 chain B against the predicted model P05155: TM-score 0.99, RMSD 0.61 Å
- 8W18 chain I against the predicted model P05155: TM-score 0.99, RMSD 0.77 Å
- 5DUQ chain A against the predicted model P05155: TM-score 0.99, RMSD 1.07 Å
- 5DUQ chain A against the predicted model P05155: TM-score 0.99, RMSD 1.07 Å
- 5DUQ chain B against the predicted model P05155: TM-score 0.98, RMSD 0.96 Å
- 5DUQ chain B against the predicted model P05155: TM-score 0.98, RMSD 0.96 Å
- 7AKV chain A against the predicted model P05155: TM-score 0.98, RMSD 1.16 Å
Elsewhere
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