MolNFT v1 · #116914 · protein
Crystal structure of the TTC7B/HYCCIN complex
5DSE · Tetratricopeptide repeat protein 7B: “Crystal structure of the TTC7B/HYCCIN complex”. X-ray diffraction, 20 pockets (best druggability 0.74). MolNFT v1 #116914 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5DSE
- Type
- protein
- Length
- 1,744 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tetratricopeptide repeat protein 7B; Hyccin
- UniProt
- Q86TV6, Q9BYI3
- Pockets
- 20 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 71% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tetratricopeptide repeat protein 7B | protein | 537 | 78% helix, 0% strand | Q86TV6 |
| B | Hyccin | protein | 231 | 62% helix, 4% strand | Q9BYI3 |
| C | Tetratricopeptide repeat protein 7B | protein | 712 | 73% helix, 0% strand | Q86TV6 |
| D | Hyccin | protein | 264 | 61% helix, 4% strand | Q9BYI3 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1111 | 0.74 | 0.77 | 86 | empty |
| 2 | 1101 | 0.74 | 0.77 | 90 | empty |
| 3 | 592 | 0.67 | 0.77 | 58 | empty |
| 4 | 443 | 0.65 | 0.78 | 37 | empty |
| 5 | 238 | 0.59 | 0.79 | 27 | empty |
Interfaces
4 interfaces between chains.
- C–D · 3146 Ų buried · 28 hydrogen bonds · protein-protein
- A–B · 2705 Ų buried · 25 hydrogen bonds · protein-protein
- A–C · 965 Ų buried · 22 hydrogen bonds · protein-protein
- A–D · 15 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- Q9BYI3 · AlphaFold monomer V2.0 prediction for hyccin (Q9BYI3) · a predicted model of the same protein · chain B against A, TM-score 1.00
- Q86TV6 · AlphaFold monomer V2.0 prediction for tetratricopeptide repeat protein 7B (Q86TV6) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86TV6
- Every structure of UniProt Q9BYI3
- Elsewhere: RCSB PDB 5DSE · PDBe 5DSE · UniProt Q86TV6 · UniProt Q9BYI3
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