MolNFT v1 · #116736 · protein
Crystal structure of mouse ERF1 in complex with reverse transcriptase (rt) of moloney murine leukemia virus
5DMQ · Reverse TRANSCRIPTASE/RIBONUCLEASE H P80: “Crystal structure of mouse ERF1 in complex with reverse transcriptase (rt) of moloney murine leukemia virus”. X-ray diffraction, 12 pockets (best druggability 0.65). MolNFT v1 #116736 on…
- PDB
- 5DMQ
- Type
- protein
- Length
- 1,004 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Reverse TRANSCRIPTASE/RIBONUCLEASE H P80; Eukaryotic peptide chain release factor subunit…
- EC
- 2.7.7.49, 2.7.7.7, 3.1.26.4
- UniProt
- P03355, Q8BWY3
- Pockets
- 12 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Reverse TRANSCRIPTASE/RIBONUCLEASE H P80 (EC 2.7.7.49, 2.7.7.7, 3.1.26.4) | protein | 609 | 32% helix, 20% strand | P03355 |
| B | Eukaryotic peptide chain release factor subunit 1 | protein | 395 | 36% helix, 21% strand | Q8BWY3 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 505 | 0.65 | 0.77 | 51 | empty |
| 2 | 408 | 0.63 | 0.77 | 41 | empty |
| 3 | 286 | 0.61 | 0.79 | 44 | empty |
| 4 | 257 | 0.57 | 0.78 | 31 | empty |
| 5 | 199 | 0.54 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 854 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5DMQ · Crystal structure of mouse eRF1 in complex with Reverse Transcriptase (RT) of Moloney… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8BWY3 · AlphaFold monomer V2.0 prediction for eukaryotic peptide chain release factor subunit 1… · a predicted model of the same protein · chain B against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03355
- Every structure of UniProt Q8BWY3
- Elsewhere: RCSB PDB 5DMQ · PDBe 5DMQ · UniProt P03355 · UniProt Q8BWY3
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