Research workbench
Crystal structure of mouse ERF1 in complex with reverse transcriptase (rt) of moloney murine leukemia virus
Analyse Crystal structure of mouse ERF1 in complex with reverse transcriptase (rt) of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5DMQ
- Type
- protein
- Length
- 1,004 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Reverse TRANSCRIPTASE/RIBONUCLEASE H P80; Eukaryotic peptide chain release factor subunit…
- EC
- 2.7.7.49, 2.7.7.7, 3.1.26.4
- UniProt
- P03355, Q8BWY3
- Pockets
- 12 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Reverse TRANSCRIPTASE/RIBONUCLEASE H P80 (EC 2.7.7.49, 2.7.7.7, 3.1.26.4) | protein | 609 | 32% helix, 20% strand | P03355 |
| B | Eukaryotic peptide chain release factor subunit 1 | protein | 395 | 36% helix, 21% strand | Q8BWY3 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 505 | 0.65 | 0.77 | 51 | empty |
| 2 | 408 | 0.63 | 0.77 | 41 | empty |
| 3 | 286 | 0.61 | 0.79 | 44 | empty |
| 4 | 257 | 0.57 | 0.78 | 31 | empty |
| 5 | 199 | 0.54 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 854 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5DMQ · Crystal structure of mouse eRF1 in complex with Reverse Transcriptase (RT) of Moloney… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8BWY3 · AlphaFold monomer V2.0 prediction for eukaryotic peptide chain release factor subunit 1… · a predicted model of the same protein · chain B against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03355
- Every structure of UniProt Q8BWY3
- Elsewhere: RCSB PDB 5DMQ · PDBe 5DMQ · UniProt P03355 · UniProt Q8BWY3
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