MolNFT v1 · #116656 · protein
Crystal structure of the bromodomain of human brm (SMARCA2) in complex with pfi-3 chemical probe
5DKC · Probable global transcription activator SNF2L2: “Crystal structure of the bromodomain of human brm (SMARCA2) in complex with pfi-3 chemical probe”. X-ray diffraction, 2 ligands (5BW, ZN), 1 pocket (best druggability 0.49). MolNFT v1…
- PDB
- 5DKC
- Type
- protein
- Length
- 110 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable global transcription activator SNF2L2
- EC
- 3.6.4.-
- UniProt
- P51531
- Ligands
- 5BW, ZN
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 65% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable global transcription activator SNF2L2 (EC 3.6.4.-) | protein | 110 | 65% helix, 2% strand | P51531 |
Ligands and binding sites
- 5BW · (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one · ligand · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.49 | 0.85 | 15 | 5BW |
Compared structures
- 5DKC · Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3… · the same entry in another collection · chain A against A, TM-score 1.00
- P51531 · AlphaFold monomer V2.0 prediction for probable global transcription activator SNF2L2… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51531
- Elsewhere: RCSB PDB 5DKC · PDBe 5DKC · UniProt P51531
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.