MolNFT v1 · #116501 · protein
Structure of tetrahymena telomerase P19 fused to mbp
5DFM · Maltose-binding periplasmic PROTEIN,TELOMERASE-associated…: “Structure of tetrahymena telomerase P19 fused to mbp”. X-ray diffraction, 2 ligands (GLC, SO4), 13 pockets (best druggability 0.81). MolNFT v1 #116501 on GenesisL1: 3D…
- PDB
- 5DFM
- Type
- protein
- Length
- 1,015 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic PROTEIN,TELOMERASE-associated protein 19
- UniProt
- P0AEY0, D2CVN7
- Ligands
- GLC, SO4
- Pockets
- 13 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic PROTEIN,TELOMERASE-associated protein 19 | protein | 509 | 40% helix, 25% strand | P0AEY0, D2CVN7 |
| B | Maltose-binding periplasmic PROTEIN,TELOMERASE-associated protein 19 | protein | 506 | 40% helix, 26% strand | P0AEY0, D2CVN7 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 4 copies · chains A, B
- SO4 · Sulfate ion · ion · 15 copies · chains A, B
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 958 | 0.81 | 0.82 | 92 | GLC |
| 2 | 171 | 0.78 | 0.94 | 33 | empty |
| 3 | 578 | 0.73 | 0.81 | 56 | GLC, SO4, GOL |
| 4 | 455 | 0.67 | 0.79 | 46 | empty |
| 5 | 315 | 0.65 | 0.81 | 38 | SO4 |
Interfaces
1 interface between chains.
- A–B · 2212 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- D2CVN7 · AlphaFold monomer V2.0 prediction for telomerase-associated protein of 19 kda (D2CVN7) · a predicted model of the same protein · chain B against A, TM-score 0.15
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEY0
- Every structure of UniProt D2CVN7
- Elsewhere: RCSB PDB 5DFM · PDBe 5DFM · UniProt P0AEY0 · UniProt D2CVN7
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