MolNFT v1 · #115835 · protein
Crystal structure of CK2ALPHA with a novel closed conformation of the ad loop
5CVG · Casein kinase II subunit alpha: “Crystal structure of CK2ALPHA with a novel closed conformation of the ad loop”. X-ray diffraction, 4 pockets (best druggability 0.62). MolNFT v1 #115835 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5CVG
- Type
- protein
- Length
- 326 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Casein kinase II subunit alpha
- EC
- 2.7.11.1
- UniProt
- P68400
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Casein kinase II subunit alpha (EC 2.7.11.1) | protein | 326 | 39% helix, 16% strand | P68400 |
Ligands and binding sites
- ACT · Acetate ion · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 275 | 0.62 | 0.80 | 36 | ACT |
| 2 | 56 | 0.42 | 0.82 | 12 | empty |
| 3 | 50 | 0.30 | 0.76 | 15 | empty |
| 4 | 61 | 0.27 | 0.73 | 14 | ACT |
Compared structures
- 5CVG · Crystal Structure of CK2alpha with a novel closed conformation of the aD loop · the same entry in another collection · chain A against A, TM-score 1.00
- P68400 · AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha (P68400) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68400
- Elsewhere: RCSB PDB 5CVG · PDBe 5CVG · UniProt P68400
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