MolNFT v1 · #115779 · protein
Crystal structure of human SART3/TIP110 nls-mouse importin alpha complex
5CTT · Importin subunit alpha-1: “Crystal structure of human SART3/TIP110 nls-mouse importin alpha complex”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #115779 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5CTT
- Type
- protein
- Length
- 442 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Squamous cell carcinoma antigen recognized by T-cells 3
- UniProt
- P52293, Q15020
- Pockets
- 2 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-1 | protein | 426 | 73% helix, 0% strand | P52293 |
| B | Squamous cell carcinoma antigen recognized by T-cells 3 | protein | 16 | 0% helix, 0% strand | Q15020 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.45 | 0.81 | 13 | empty |
| 2 | 56 | 0.26 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1408 Ų buried · 46 hydrogen bonds · protein-protein
Compared structures
- 5CTT · Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q15020 · AlphaFold monomer V2.0 prediction for squamous cell carcinoma antigen recognized by… · a predicted model of the same protein · chain B against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt Q15020
- Elsewhere: RCSB PDB 5CTT · PDBe 5CTT · UniProt P52293 · UniProt Q15020
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