MolNFT v1 · #115755 · protein
The structure of the NK1 fragment of HGF/SF complexed with caps
5CT2 · Hepatocyte growth factor: “The structure of the NK1 fragment of HGF/SF complexed with caps”. X-ray diffraction, 4 pockets (best druggability 0.71). MolNFT v1 #115755 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5CT2
- Type
- protein
- Length
- 346 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hepatocyte growth factor
- UniProt
- P14210
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hepatocyte growth factor | protein | 173 | 11% helix, 30% strand | P14210 |
| B | Hepatocyte growth factor | protein | 173 | 12% helix, 30% strand | P14210 |
Ligands and binding sites
- CXS · 3-cyclohexyl-1-propylsulfonic acid · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 498 | 0.71 | 0.80 | 58 | empty |
| 2 | 238 | 0.58 | 0.79 | 53 | empty |
| 3 | 165 | 0.48 | 0.77 | 29 | empty |
| 4 | 121 | 0.40 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1245 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 5CT2 · The structure of the NK1 fragment of HGF/SF complexed with CAPS · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14210
- Elsewhere: RCSB PDB 5CT2 · PDBe 5CT2 · UniProt P14210
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.