MolNFT v1 · #115729 · protein
Structure of an open form of chicken heart citrate synthase at 2.8 ångströms resolution
5CSC: “Structure of an open form of chicken heart citrate synthase at 2.8 ångströms resolution”. X-ray diffraction, 10 pockets (best druggability 0.69). MolNFT v1 #115729 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5CSC
- Type
- protein
- Length
- 858 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Citrate synthase
- EC
- 4.1.3.7
- UniProt
- P23007
- Pockets
- 10 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Citrate synthase (EC 4.1.3.7) | protein | 429 | 56% helix, 3% strand | P23007 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 501 | 0.69 | 0.79 | 45 | empty |
| 2 | 493 | 0.68 | 0.79 | 43 | empty |
| 3 | 199 | 0.58 | 0.80 | 30 | empty |
| 4 | 215 | 0.57 | 0.80 | 31 | empty |
| 5 | 141 | 0.55 | 0.82 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 4141 Ų buried · 51 hydrogen bonds · protein-protein
Compared structures
- 5CSC · Structure of an open form of chicken heart citrate synthase at 2.8 ångströms resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23007
- Elsewhere: RCSB PDB 5CSC · PDBe 5CSC · UniProt P23007
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