Research workbench
Structure of an open form of chicken heart citrate synthase at 2.8 ångströms resolution
Analyse Structure of an open form of chicken heart citrate synthase at 2.8 ångströms… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CSC
- Type
- protein
- Length
- 858 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Citrate synthase
- EC
- 4.1.3.7
- UniProt
- P23007
- Pockets
- 10 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Citrate synthase (EC 4.1.3.7) | protein | 429 | 56% helix, 3% strand | P23007 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 501 | 0.69 | 0.79 | 45 | empty |
| 2 | 493 | 0.68 | 0.79 | 43 | empty |
| 3 | 199 | 0.58 | 0.80 | 30 | empty |
| 4 | 215 | 0.57 | 0.80 | 31 | empty |
| 5 | 141 | 0.55 | 0.82 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 4141 Ų buried · 51 hydrogen bonds · protein-protein
Compared structures
- 5CSC · Structure of an open form of chicken heart citrate synthase at 2.8 ångströms resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23007
- Elsewhere: RCSB PDB 5CSC · PDBe 5CSC · UniProt P23007
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