Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 3'- hydroxyacetophenone (sgc - diamond I04-1 fragment screening)

Structure

x-ray diffraction · 1 distinct chain · 59% helix, 0% strand (DSSP).

Ligands and binding sites

• 53C · 1-(3-hydroxyphenyl)ethanone · ligand · chains A
• CL · Chloride ion · ion · chains A
• SO4 · Sulfate ion · ion · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 5CQ4 · Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9UIF8 · AlphaFold monomer V2.0 prediction for bromodomain adjacent to zinc finger domain protein… · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9UIF8
• Elsewhere: RCSB PDB 5CQ4 · PDBe 5CQ4 · UniProt Q9UIF8