MolNFT v1 · #115519 · protein
Structural basis for the selectivity of guanine nucleotide exchange factors for the small G-protein ral
5CM9 · Ral guanine nucleotide dissociation stimulator-like 2: “Structural basis for the selectivity of guanine nucleotide exchange factors for the small G-protein ral”. X-ray diffraction, 12 pockets (best druggability 0.63). MolNFT v1…
- PDB
- 5CM9
- Type
- protein
- Length
- 1,097 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ral guanine nucleotide dissociation stimulator-like 2; RAS-related protein ral-a
- UniProt
- Q61193, P48555
- Pockets
- 12 · best druggability 0.63
Structure
x-ray diffraction · 4 distinct chains · 55% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ral guanine nucleotide dissociation stimulator-like 2 | protein | 405 | 60% helix, 8% strand | Q61193 |
| B | Ral guanine nucleotide dissociation stimulator-like 2 | protein | 396 | 60% helix, 9% strand | Q61193 |
| C | RAS-related protein ral-a | protein | 146 | 41% helix, 27% strand | P48555 |
| D | RAS-related protein ral-a | protein | 150 | 41% helix, 26% strand | P48555 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 285 | 0.63 | 0.80 | 44 | empty |
| 2 | 240 | 0.58 | 0.80 | 35 | empty |
| 3 | 226 | 0.57 | 0.79 | 31 | empty |
| 4 | 237 | 0.56 | 0.78 | 40 | empty |
| 5 | 260 | 0.54 | 0.76 | 26 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1319 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 1318 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 248 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 5CM9 · Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small… · the same entry in another collection · chain D against D, TM-score 1.00
- Q61193 · AlphaFold monomer V2.0 prediction for ral guanine nucleotide dissociation stimulator-like… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P48555 · AlphaFold monomer V2.0 prediction for RAS-related protein ral-a (P48555) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61193
- Every structure of UniProt P48555
- Elsewhere: RCSB PDB 5CM9 · PDBe 5CM9 · UniProt Q61193 · UniProt P48555
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