MolNFT v1 · #115518 · protein
Structural basis for the selectivity of guanine nucleotide exchange factors for the small G-protein ral
5CM8 · Ral guanine nucleotide dissociation stimulator-like 2: “Structural basis for the selectivity of guanine nucleotide exchange factors for the small G-protein ral”. X-ray diffraction, 5 pockets (best druggability 0.67). MolNFT v1…
- PDB
- 5CM8
- Type
- protein
- Length
- 588 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ral guanine nucleotide dissociation stimulator-like 2; RAS-related protein ral-a
- UniProt
- Q61193, P48555
- Pockets
- 5 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ral guanine nucleotide dissociation stimulator-like 2 | protein | 419 | 60% helix, 9% strand | Q61193 |
| B | RAS-related protein ral-a | protein | 169 | 33% helix, 22% strand | P48555 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 488 | 0.67 | 0.78 | 63 | empty |
| 2 | 73 | 0.51 | 0.84 | 18 | empty |
| 3 | 123 | 0.48 | 0.79 | 27 | empty |
| 4 | 82 | 0.38 | 0.77 | 26 | empty |
| 5 | 72 | 0.30 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1810 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 5CM8 · Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small… · the same entry in another collection · chain A against A, TM-score 1.00
- Q61193 · AlphaFold monomer V2.0 prediction for ral guanine nucleotide dissociation stimulator-like… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P48555 · AlphaFold monomer V2.0 prediction for RAS-related protein ral-a (P48555) · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61193
- Every structure of UniProt P48555
- Elsewhere: RCSB PDB 5CM8 · PDBe 5CM8 · UniProt Q61193 · UniProt P48555
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