MolNFT v1 · #115421 · protein
Crystal structure of amino acids 1562-1622 of MYH7
5CJ4 · XRCC4-MYH7-(1562-1622) chimera protein: “Crystal structure of amino acids 1562-1622 of MYH7”. X-ray diffraction, 7 pockets (best druggability 0.47). MolNFT v1 #115421 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5CJ4
- Type
- protein
- Length
- 770 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- XRCC4-MYH7-(1562-1622) chimera protein
- UniProt
- Q13426, P12883
- Pockets
- 7 · best druggability 0.47
Structure
x-ray diffraction · 4 distinct chains · 53% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | XRCC4-MYH7-(1562-1622) chimera protein | protein | 194 | 54% helix, 27% strand | Q13426, P12883 |
| B | XRCC4-MYH7-(1562-1622) chimera protein | protein | 190 | 51% helix, 27% strand | Q13426, P12883 |
| C | XRCC4-MYH7-(1562-1622) chimera protein | protein | 197 | 55% helix, 27% strand | Q13426, P12883 |
| D | XRCC4-MYH7-(1562-1622) chimera protein | protein | 189 | 53% helix, 30% strand | Q13426, P12883 |
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 194 | 0.47 | 0.75 | 27 | empty |
| 2 | 113 | 0.46 | 0.79 | 21 | empty |
| 3 | 114 | 0.45 | 0.78 | 21 | empty |
| 4 | 85 | 0.42 | 0.79 | 15 | empty |
| 5 | 72 | 0.38 | 0.78 | 14 | empty |
Interfaces
3 interfaces between chains.
- C–D · 2570 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 2413 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 258 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 60 modified (methylation).
Compared structures
- 5CJ4 · Crystal Structure of Amino Acids 1562-1622 of MYH7 · the same entry in another collection · chain A against A, TM-score 1.00
- Q13426 · AlphaFold monomer V2.0 prediction for DNA repair protein XRCC4 (Q13426) · a predicted model of the same protein · chain D against A, TM-score 0.86
- P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain D against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13426
- Every structure of UniProt P12883
- Elsewhere: RCSB PDB 5CJ4 · PDBe 5CJ4 · UniProt Q13426 · UniProt P12883
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