MolNFT v1 · #115304 · protein
Crystal structure of proliferating cell nuclear antigen from leishmania donovani at 3.2 a resolution
5CFK · Proliferating cell nuclear ANTIGEN,PROLIFERATING cell…: “Crystal structure of proliferating cell nuclear antigen from leishmania donovani at 3.2 a resolution”. X-ray diffraction, 12 pockets (best druggability 0.72). MolNFT v1…
- PDB
- 5CFK
- Type
- protein
- Length
- 1,518 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proliferating cell nuclear ANTIGEN,PROLIFERATING cell nuclear antigen
- UniProt
- B5TV91
- Pockets
- 12 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 19% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Proliferating cell nuclear ANTIGEN,PROLIFERATING cell nuclear antigen | protein | 253 | 19% helix, 43% strand | B5TV91 |
Pockets
12 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 897 | 0.72 | 0.76 | 88 | empty |
| 2 | 653 | 0.67 | 0.76 | 61 | empty |
| 3 | 80 | 0.43 | 0.80 | 15 | empty |
| 4 | 111 | 0.41 | 0.76 | 17 | empty |
| 5 | 126 | 0.38 | 0.73 | 22 | empty |
Interfaces
11 interfaces between chains.
- D–E · 735 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 676 Ų buried · 10 hydrogen bonds · protein-protein
- C–F · 660 Ų buried · 7 hydrogen bonds · protein-protein
- A–E · 657 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 656 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 5CFK · Crystal structure of Proliferating Cell Nuclear Antigen from Leishmania donovani at 3.2 A… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B5TV91
- Elsewhere: RCSB PDB 5CFK · PDBe 5CFK · UniProt B5TV91
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