MolNFT v1 · #115259 · protein
Structure of tyrosinase from walnut (juglans regia)
5CE9 · Polyphenol oxidase: “Structure of tyrosinase from walnut (juglans regia)”. X-ray diffraction, 3 ligands (NA, CU, O), 6 pockets (best druggability 0.53). MolNFT v1 #115259 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5CE9
- Type
- protein
- Length
- 671 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polyphenol oxidase
- UniProt
- C0LU17
- Ligands
- NA, CU, O
- Pockets
- 6 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polyphenol oxidase | protein | 339 | 38% helix, 8% strand | C0LU17 |
| B | Polyphenol oxidase | protein | 332 | 38% helix, 9% strand | C0LU17 |
Ligands and binding sites
- NA · Sodium ion · metal · 7 copies · chains A, B
- CU · Copper (II) ion · metal · 4 copies · chains A, B
- O · Oxygen atom · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 217 | 0.53 | 0.77 | 28 | empty |
| 2 | 142 | 0.44 | 0.76 | 17 | empty |
| 3 | 98 | 0.40 | 0.77 | 20 | empty |
| 4 | 54 | 0.31 | 0.76 | 12 | empty |
| 5 | 64 | 0.31 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 571 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5CE9 · structure of tyrosinase from walnut (Juglans regia) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C0LU17
- Elsewhere: RCSB PDB 5CE9 · PDBe 5CE9 · UniProt C0LU17
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.