MolNFT v1 · #114995 · protein
Structural insights into the SCC2-SCC4 cohesin loader
5C6G · AGR133CP: “Structural insights into the SCC2-SCC4 cohesin loader”. X-ray diffraction, 19 pockets (best druggability 0.78). MolNFT v1 #114995 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5C6G
- Type
- protein
- Length
- 1,440 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- AGR133CP; Sister chromatid cohesion protein 2
- UniProt
- Q74ZR5, Q750S2
- Pockets
- 19 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 65% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | AGR133CP | protein | 605 | 74% helix, 2% strand | Q74ZR5 |
| B | Sister chromatid cohesion protein 2 | protein | 126 | 21% helix, 9% strand | Q750S2 |
| C | AGR133CP | protein | 588 | 74% helix, 2% strand | Q74ZR5 |
| D | Sister chromatid cohesion protein 2 | protein | 121 | 22% helix, 7% strand | Q750S2 |
Pockets
19 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 859 | 0.78 | 0.81 | 79 | empty |
| 2 | 1076 | 0.74 | 0.77 | 75 | empty |
| 3 | 400 | 0.64 | 0.78 | 35 | empty |
| 4 | 135 | 0.64 | 0.87 | 21 | empty |
| 5 | 163 | 0.63 | 0.85 | 22 | empty |
Interfaces
4 interfaces between chains.
- A–B · 6215 Ų buried · 69 hydrogen bonds · protein-protein
- C–D · 6065 Ų buried · 69 hydrogen bonds · protein-protein
- A–C · 142 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 122 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5C6G · Structural Insights into the Scc2-Scc4 Cohesin Loader · the same entry in another collection · chain A against A, TM-score 1.00
- Q750S2 · AlphaFold monomer V2.0 prediction for sister chromatid cohesion protein 2 (Q750S2) · a predicted model of the same protein · chain D against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q74ZR5
- Every structure of UniProt Q750S2
- Elsewhere: RCSB PDB 5C6G · PDBe 5C6G · UniProt Q74ZR5 · UniProt Q750S2
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