MolNFT v1 · #114838 · protein

SERINE/THREONINE-protein kinase pim-1

5C1Q: “SERINE/THREONINE-protein kinase pim-1”. X-ray diffraction, 1 ligand (4YK), 2 pockets (best druggability 0.64). MolNFT v1 #114838 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5C1Q
Type: protein
Length: 273 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase pim-1
EC: 2.7.11.1
UniProt: P11309
Ligands: 4YK
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	SERINE/THREONINE-protein kinase pim-1 (EC 2.7.11.1)	protein	273	39% helix, 23% strand	P11309

Ligands and binding sites

4YK · 3-methoxy[1]benzothieno[2,3-c]quinolin-6(5H)-one · ligand · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	252	0.64	0.81	26	4YK
2	125	0.52	0.81	22	empty

Compared structures

5C1Q · Serine/threonine-protein kinase pim-1 · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11309
Elsewhere: RCSB PDB 5C1Q · PDBe 5C1Q · UniProt P11309

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