MolNFT v1 · #114719 · protein
The structure of RPF2-RRS1 explains its role in ribosome biogenesis
5BY8: “The structure of RPF2-RRS1 explains its role in ribosome biogenesis”. X-ray diffraction, 4 pockets (best druggability 0.53). MolNFT v1 #114719 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5BY8
- Type
- protein
- Length
- 316 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RPF2; RRS1
- UniProt
- C8VMF9, Q5B6T5
- Pockets
- 4 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RPF2 | protein | 231 | 22% helix, 35% strand | C8VMF9 |
| B | RRS1 | protein | 85 | 31% helix, 19% strand | Q5B6T5 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.53 | 0.80 | 19 | empty |
| 2 | 82 | 0.46 | 0.81 | 22 | empty |
| 3 | 110 | 0.43 | 0.77 | 23 | empty |
| 4 | 133 | 0.40 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 2634 Ų buried · 35 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 5BY8 · The structure of Rpf2-Rrs1 explains its role in ribosome biogenesis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C8VMF9
- Every structure of UniProt Q5B6T5
- Elsewhere: RCSB PDB 5BY8 · PDBe 5BY8 · UniProt C8VMF9 · UniProt Q5B6T5
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