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The structure of RPF2-RRS1 explains its role in ribosome biogenesis

Analyse The structure of RPF2-RRS1 explains its role in ribosome biogenesis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5BY8
Type: protein
Length: 316 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RPF2; RRS1
UniProt: C8VMF9, Q5B6T5
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RPF2	protein	231	22% helix, 35% strand	C8VMF9
B	RRS1	protein	85	31% helix, 19% strand	Q5B6T5

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	147	0.53	0.80	19	empty
2	82	0.46	0.81	22	empty
3	110	0.43	0.77	23	empty
4	133	0.40	0.74	21	empty

Interfaces

1 interface between chains.

A–B · 2634 Å² buried · 35 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 modified (engineered).

Compared structures

5BY8 · The structure of Rpf2-Rrs1 explains its role in ribosome biogenesis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C8VMF9
Every structure of UniProt Q5B6T5
Elsewhere: RCSB PDB 5BY8 · PDBe 5BY8 · UniProt C8VMF9 · UniProt Q5B6T5

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