MolNFT v1 · #114692 · protein
Apo fcrn structure at pH 4.5
5BXF · IgG receptor fcrn large subunit P51: “Apo fcrn structure at pH 4.5”. X-ray diffraction, 5 pockets (best druggability 0.76). MolNFT v1 #114692 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5BXF
- Type
- protein
- Length
- 724 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IgG receptor fcrn large subunit P51; Beta-2-microglobulin
- UniProt
- P55899, P61769
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | IgG receptor fcrn large subunit P51 | protein | 263 | 25% helix, 40% strand | P55899 |
| B, D | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1116 | 0.76 | 0.78 | 111 | empty |
| 2 | 201 | 0.54 | 0.78 | 28 | empty |
| 3 | 213 | 0.51 | 0.77 | 29 | empty |
| 4 | 173 | 0.44 | 0.74 | 25 | empty |
| 5 | 112 | 0.35 | 0.73 | 23 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1523 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 1458 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 998 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 138 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 132 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 5BXF · Apo FcRn Structure at pH 4.5 · the same entry in another collection · chain D against D, TM-score 1.00
- P55899 · AlphaFold monomer V2.0 prediction for IgG receptor fcrn large subunit P51 (P55899) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55899
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 5BXF · PDBe 5BXF · UniProt P55899 · UniProt P61769
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