MolNFT v1 · #114551 · protein
Histone chaperone HIF1 playing with histone H2A-H2B dimer
5BT1 · HAT1-interacting factor 1: “Histone chaperone HIF1 playing with histone H2A-H2B dimer”. X-ray diffraction, 9 pockets (best druggability 0.73). MolNFT v1 #114551 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5BT1
- Type
- protein
- Length
- 668 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HAT1-interacting factor 1; Histone H2A.1; Histone H2B.1
- UniProt
- Q12373, P04911, P02293
- Pockets
- 9 · best druggability 0.73
Structure
x-ray diffraction · 4 distinct chains · 68% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HAT1-interacting factor 1 | protein | 244 | 66% helix, 0% strand | Q12373 |
| B | HAT1-interacting factor 1 | protein | 249 | 67% helix, 0% strand | Q12373 |
| C | Histone H2A.1 | protein | 85 | 67% helix, 5% strand | P04911 |
| D | Histone H2B.1 | protein | 90 | 77% helix, 4% strand | P02293 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 969 | 0.73 | 0.76 | 69 | empty |
| 2 | 221 | 0.56 | 0.79 | 30 | empty |
| 3 | 282 | 0.55 | 0.76 | 34 | empty |
| 4 | 102 | 0.49 | 0.82 | 20 | empty |
| 5 | 78 | 0.40 | 0.79 | 14 | empty |
Interfaces
4 interfaces between chains.
- C–D · 2427 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 789 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 658 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 600 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5BT1 · histone chaperone Hif1 playing with histone H2A-H2B dimer · the same entry in another collection · chain D against D, TM-score 1.00
- P02293 · AlphaFold monomer V2.0 prediction for histone H2B.1 (P02293) · a predicted model of the same protein · chain D against A, TM-score 0.97
- P04911 · AlphaFold monomer V2.0 prediction for histone H2A.1 (P04911) · a predicted model of the same protein · chain C against A, TM-score 0.95
- Q12373 · AlphaFold monomer V2.0 prediction for HAT1-interacting factor 1 (Q12373) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12373
- Every structure of UniProt P04911
- Every structure of UniProt P02293
- Elsewhere: RCSB PDB 5BT1 · PDBe 5BT1 · UniProt Q12373 · UniProt P04911 · UniProt P02293
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.