MolNFT v1 · #114445 · protein
Crystal structure of nucleotide-free human HSP70 nbd double mutant E268Q+R272K.
5BPN · Heat shock 70 kda protein 1A: “Crystal structure of nucleotide-free human HSP70 nbd double mutant E268Q+R272K.”. X-ray diffraction, 2 ligands (PO4, CL), 2 pockets (best druggability 0.70). MolNFT v1 #114445 on GenesisL1: 3D…
- PDB
- 5BPN
- Type
- protein
- Length
- 372 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock 70 kda protein 1A
- UniProt
- P0DMV8
- Ligands
- PO4, CL
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock 70 kda protein 1A | protein | 372 | 43% helix, 29% strand | P0DMV8 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 356 | 0.70 | 0.83 | 49 | CL, PO4, TRS |
| 2 | 235 | 0.46 | 0.73 | 25 | empty |
Compared structures
- 5BPN · Crystal structure of nucleotide-free human Hsp70 NBD double mutant E268Q+R272K. · the same entry in another collection · chain A against A, TM-score 1.00
- P0DMV8 · AlphaFold monomer V2.0 prediction for heat shock 70 kda protein 1A (P0DMV8) · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DMV8
- Elsewhere: RCSB PDB 5BPN · PDBe 5BPN · UniProt P0DMV8
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