MolNFT v1 · #114363 · protein
Crystal structure of ADP bound human HSP70 nbd mutant R272K.
5BN9 · Heat shock 70 kda protein 1A: “Crystal structure of ADP bound human HSP70 nbd mutant R272K.”. X-ray diffraction, 4 ligands (ADP, NA, CL), 1 pocket (best druggability 0.75). MolNFT v1 #114363 on GenesisL1: 3D structure, binding sites…
- PDB
- 5BN9
- Type
- protein
- Length
- 379 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock 70 kda protein 1A
- UniProt
- P0DMV8
- Ligands
- ADP, NA, CL, PO4
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock 70 kda protein 1A | protein | 379 | 40% helix, 28% strand | P0DMV8 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- NA · Sodium ion · metal
- CL · Chloride ion · ion · chains A
- PO4 · Phosphate ion · ion · chains A
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 680 | 0.75 | 0.81 | 76 | ADP |
Compared structures
- 5BN9 · Crystal structure of ADP bound human Hsp70 NBD mutant R272K. · the same entry in another collection · chain A against A, TM-score 1.00
- P0DMV8 · AlphaFold monomer V2.0 prediction for heat shock 70 kda protein 1A (P0DMV8) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DMV8
- Elsewhere: RCSB PDB 5BN9 · PDBe 5BN9 · UniProt P0DMV8
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