MolNFT v1 · #114325 · protein

Cancer-associated SHP2/T507K mutant

5BK8 · Tyrosine-protein phosphatase non-receptor type 11: “Cancer-associated SHP2/T507K mutant”. X-ray diffraction, 4 pockets (best druggability 0.70). MolNFT v1 #114325 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5BK8
Type: protein
Length: 498 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 11
EC: 3.1.3.48
UniProt: Q06124
Pockets: 4 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)	protein	498	30% helix, 27% strand	Q06124

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	659	0.70	0.78	70	empty
2	82	0.50	0.83	19	empty
3	120	0.40	0.75	25	empty
4	56	0.28	0.74	13	empty

Compared structures

5BK8 · Cancer-associated SHP2/T507K mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06124
Elsewhere: RCSB PDB 5BK8 · PDBe 5BK8 · UniProt Q06124

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