MolNFT v1 · #114310 · protein
Crystal structure of human fcrn with a peptide inhibitor at multiple sites
5BJT · IgG receptor fcrn large subunit P51: “Crystal structure of human fcrn with a peptide inhibitor at multiple sites”. X-ray diffraction, 20 pockets (best druggability 0.76). MolNFT v1 #114310 on GenesisL1: 3D structure, binding sites…
- PDB
- 5BJT
- Type
- protein
- Length
- 1,560 residues
- Chains
- 15
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IgG receptor fcrn large subunit P51; Beta-2-microglobulin; Peptide inhibitor
- UniProt
- P55899, P61769
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 17% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | IgG receptor fcrn large subunit P51 | protein | 263 | 24% helix, 41% strand | P55899 |
| B, D, F, H | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| P, Q, R, S, T, U, V | Peptide inhibitor | protein | 16 | 0% helix, 6% strand | — |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1110 | 0.76 | 0.79 | 105 | empty |
| 2 | 611 | 0.72 | 0.80 | 61 | empty |
| 3 | 659 | 0.67 | 0.76 | 58 | empty |
| 4 | 504 | 0.65 | 0.77 | 55 | empty |
| 5 | 442 | 0.63 | 0.77 | 48 | empty |
Interfaces
30 interfaces between chains.
- E–F · 1375 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 1371 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1343 Ų buried · 15 hydrogen bonds · protein-protein
- G–H · 1209 Ų buried · 13 hydrogen bonds · protein-protein
- E–R · 505 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide (disulfide).
Compared structures
- 5BJT · Crystal structure of human FcRn with a peptide inhibitor at multiple sites · the same entry in another collection · chain V against V, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55899
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 5BJT · PDBe 5BJT · UniProt P55899 · UniProt P61769
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.