MolNFT v1 · #114280 · protein
Human FGFR1 kinase in complex with CH5183284
5B7V · Fibroblast growth factor receptor 1: “Human FGFR1 kinase in complex with CH5183284”. X-ray diffraction, 2 ligands (LWJ, SO4), 4 pockets (best druggability 0.73). MolNFT v1 #114280 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5B7V
- Type
- protein
- Length
- 559 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 1
- EC
- 2.7.10.1
- UniProt
- P11362
- Ligands
- LWJ, SO4
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 282 | 39% helix, 15% strand | P11362 |
| B | Fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 277 | 40% helix, 16% strand | P11362 |
Ligands and binding sites
- LWJ · [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 759 | 0.73 | 0.78 | 90 | empty |
| 2 | 562 | 0.68 | 0.77 | 55 | LWJ |
| 3 | 606 | 0.67 | 0.77 | 58 | LWJ |
| 4 | 62 | 0.27 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 481 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11362
- Elsewhere: RCSB PDB 5B7V · PDBe 5B7V · UniProt P11362
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