MolNFT v1 · #11426 · protein + DNA

Single stranded DNA-binding domain of human replication protein a bound to single stranded DNA, RPA70 subunit, residues 183-420

1JMC · DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*C)-3'): “Single stranded DNA-binding domain of human replication protein a bound to single stranded DNA, RPA70…”. X-ray diffraction, 2 pockets (best druggability 0.61). MolNFT v1 #11426 on GenesisL1…

PDB: 1JMC
Type: protein + DNA
Length: 246 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*C)-3'); Protein (replication protein a (rpa))
UniProt: P27694
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	DNA (5'-D(CPCPCPCPCPCPCPC)-3')	dna	8	—	—
A	Protein (replication protein a (rpa))	protein	238	18% helix, 42% strand	P27694

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	303	0.61	0.79	48	empty
2	65	0.32	0.77	17	empty

Interfaces

1 interface between chains.

B–A · 1112 Å² buried · 27 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1JMC · Single stranded DNA-binding domain of human replication protein a bound to single… · the same entry in another collection · chain B against B, TM-score 1.00
P27694 · AlphaFold monomer V2.0 prediction for replication protein a 70 kda DNA-binding subunit… · a predicted model of the same protein · chain A against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P27694
Elsewhere: RCSB PDB 1JMC · PDBe 1JMC · UniProt P27694

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