MolNFT v1 · #114182 · protein
Structure analysis of function associated loop mutant of substrate recognition domain of FBS1 ubiquitin ligase
5B4N · F-box only protein 2: “Structure analysis of function associated loop mutant of substrate recognition domain of FBS1 ubiquitin ligase”. X-ray diffraction, 2 pockets (best druggability 0.69). MolNFT v1 #114182 on GenesisL1: 3D…
- PDB
- 5B4N
- Type
- protein
- Length
- 348 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-box only protein 2
- UniProt
- Q80UW2
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | F-box only protein 2 | protein | 174 | 9% helix, 41% strand | Q80UW2 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 246 | 0.69 | 0.85 | 48 | empty |
| 2 | 80 | 0.35 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 721 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 5B4N · Structure analysis of function associated loop mutant of substrate recognition domain of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q80UW2 · AlphaFold monomer V2.0 prediction for F-box only protein 2 (Q80UW2) · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80UW2
- Elsewhere: RCSB PDB 5B4N · PDBe 5B4N · UniProt Q80UW2
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