Research workbench

Structure analysis of function associated loop mutant of substrate recognition domain of FBS1 ubiquitin ligase

Analyse Structure analysis of function associated loop mutant of substrate recognition… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5B4N
Type: protein
Length: 348 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: F-box only protein 2
UniProt: Q80UW2
Pockets: 2 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 9% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	F-box only protein 2	protein	174	9% helix, 41% strand	Q80UW2

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	246	0.69	0.85	48	empty
2	80	0.35	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 721 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

5B4N · Structure analysis of function associated loop mutant of substrate recognition domain of… · the same entry in another collection · chain A against A, TM-score 1.00
Q80UW2 · AlphaFold monomer V2.0 prediction for F-box only protein 2 (Q80UW2) · a predicted model of the same protein · chain B against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q80UW2
Elsewhere: RCSB PDB 5B4N · PDBe 5B4N · UniProt Q80UW2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.