MolNFT v1 · #114034 · protein
Structure of the prenyltransferase MOEN5 with a fusion protein tag of SSO7D
5B02 · MOEN5,DNA-binding protein 7D: “Structure of the prenyltransferase MOEN5 with a fusion protein tag of SSO7D”. X-ray diffraction, 8 pockets (best druggability 0.82). MolNFT v1 #114034 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5B02
- Type
- protein
- Length
- 1,191 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MOEN5,DNA-binding protein 7D
- UniProt
- A0A010, P39476
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 4 distinct chains · 72% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MOEN5,DNA-binding protein 7D | protein | 264 | 80% helix, 0% strand | A0A010, P39476 |
| B | MOEN5,DNA-binding protein 7D | protein | 332 | 65% helix, 10% strand | A0A010, P39476 |
| C | MOEN5,DNA-binding protein 7D | protein | 262 | 80% helix, 0% strand | A0A010, P39476 |
| D | MOEN5,DNA-binding protein 7D | protein | 333 | 66% helix, 11% strand | A0A010, P39476 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 940 | 0.82 | 0.83 | 81 | empty |
| 2 | 1110 | 0.79 | 0.80 | 86 | empty |
| 3 | 640 | 0.77 | 0.82 | 65 | empty |
| 4 | 667 | 0.75 | 0.81 | 53 | empty |
| 5 | 299 | 0.58 | 0.77 | 51 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1867 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 1854 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 863 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 325 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5B02 · Structure of the prenyltransferase MoeN5 with a fusion protein tag of Sso7d · the same entry in another collection · chain C against C, TM-score 1.00
- P39476 · AlphaFold monomer V2.0 prediction for DNA-binding protein 7D (P39476) · a predicted model of the same protein · chain D against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A010
- Every structure of UniProt P39476
- Elsewhere: RCSB PDB 5B02 · PDBe 5B02 · UniProt A0A010 · UniProt P39476
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