MolNFT v1 · #11400 · protein

Human glucose-6-phosphate isomerase

1JLH · Phosphoglucose isomerase: “Human glucose-6-phosphate isomerase”. X-ray diffraction, 16 pockets (best druggability 0.77). MolNFT v1 #11400 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1JLH
Type: protein
Length: 2,224 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoglucose isomerase
EC: 5.3.1.9
UniProt: P06744
Pockets: 16 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 56% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Phosphoglucose isomerase (EC 5.3.1.9)	protein	556	56% helix, 12% strand	P06744

Pockets

16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	969	0.77	0.80	57	empty
2	974	0.77	0.79	62	empty
3	530	0.73	0.82	49	empty
4	494	0.72	0.82	49	empty
5	493	0.72	0.81	50	empty

Interfaces

2 interfaces between chains.

A–B · 6560 Å² buried · 89 hydrogen bonds · protein-protein
C–D · 6540 Å² buried · 87 hydrogen bonds · protein-protein

Compared structures

1JLH · Human Glucose-6-phosphate Isomerase · the same entry in another collection · chain D against D, TM-score 1.00
P06744 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate isomerase (P06744) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06744
Elsewhere: RCSB PDB 1JLH · PDBe 1JLH · UniProt P06744

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