MolNFT v1 · #113956 · protein

Crystal structure of THG1 like protein (tlp) with GTP

5AXL · TRNA(HIS)-5'-guanylyltransferase (THG1) like protein: “Crystal structure of THG1 like protein (tlp) with GTP”. X-ray diffraction, 2 ligands (GTP, MG), 3 pockets (best druggability 0.68). MolNFT v1 #113956 on GenesisL1: 3D structure…

PDB: 5AXL
Type: protein
Length: 442 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TRNA(HIS)-5'-guanylyltransferase (THG1) like protein
Ligands: GTP, MG
Pockets: 3 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	TRNA(HIS)-5'-guanylyltransferase (THG1) like protein	protein	221	52% helix, 16% strand	—

Ligands and binding sites

GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	366	0.68	0.81	41	GTP, MG
2	379	0.66	0.79	34	GTP
3	72	0.43	0.80	19	empty

Interfaces

1 interface between chains.

A–B · 1953 Å² buried · 41 hydrogen bonds · protein-protein

Compared structures

5AXL · Crystal structure of Thg1 like protein (TLP) with GTP · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5AXL · PDBe 5AXL

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