MolNFT v1 · #113925 · protein
The crystal structure of jnk from drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian jnk proteins.
5AWM · Stress-activated protein kinase jnk: “The crystal structure of jnk from drosophila melanogaster reveals an evolutionarily conserved topology with…”. X-ray diffraction, 2 ligands (ANP, MG), 2 pockets (best druggability 0.70). MolNFT…
- PDB
- 5AWM
- Type
- protein
- Length
- 345 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stress-activated protein kinase jnk
- EC
- 2.7.11.24
- UniProt
- P92208
- Ligands
- ANP, MG
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Stress-activated protein kinase jnk (EC 2.7.11.24) | protein | 345 | 41% helix, 15% strand | P92208 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 496 | 0.70 | 0.79 | 54 | ANP, MG |
| 2 | 60 | 0.28 | 0.73 | 17 | empty |
Compared structures
- 5AWM · The Crystal Structure of JNK from Drosophila melanogaster Reveals an Evolutionarily… · the same entry in another collection · chain A against A, TM-score 1.00
- P92208 · AlphaFold monomer V2.0 prediction for stress-activated protein kinase jnk (P92208) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P92208
- Elsewhere: RCSB PDB 5AWM · PDBe 5AWM · UniProt P92208
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