Research workbench
The crystal structure of jnk from drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian jnk proteins.
Analyse The crystal structure of jnk from drosophila melanogaster reveals an… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5AWM
- Type
- protein
- Length
- 345 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stress-activated protein kinase jnk
- EC
- 2.7.11.24
- UniProt
- P92208
- Ligands
- ANP, MG
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Stress-activated protein kinase jnk (EC 2.7.11.24) | protein | 345 | 41% helix, 15% strand | P92208 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 496 | 0.70 | 0.79 | 54 | ANP, MG |
| 2 | 60 | 0.28 | 0.73 | 17 | empty |
Compared structures
- 5AWM · The Crystal Structure of JNK from Drosophila melanogaster Reveals an Evolutionarily… · the same entry in another collection · chain A against A, TM-score 1.00
- P92208 · AlphaFold monomer V2.0 prediction for stress-activated protein kinase jnk (P92208) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P92208
- Elsewhere: RCSB PDB 5AWM · PDBe 5AWM · UniProt P92208
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