MolNFT v1 · #113685 · protein + RNA

Structure of the la crosse bunyavirus polymerase in complex with the 3' viral RNA

5AMR · RNA polymerase L: “Structure of the la crosse bunyavirus polymerase in complex with the 3' viral RNA”. X-ray diffraction, 20 pockets (best druggability 0.78). MolNFT v1 #113685 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 5AMR
Type: protein + RNA
Length: 1,681 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA polymerase L; RNA
EC: 2.7.7.48
UniProt: A5HC98
Pockets: 20 · best druggability 0.78

Structure

x-ray diffraction · 3 distinct chains · 54% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA polymerase L (EC 2.7.7.48)	protein	1657	54% helix, 12% strand	A5HC98
B	RNA	rna	16	—	—
C	RNA	rna	8	—	—

Pockets

20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	402	0.78	0.87	33	empty
2	490	0.78	0.85	42	empty
3	440	0.69	0.80	43	empty
4	314	0.68	0.82	27	empty
5	501	0.65	0.77	58	empty

Interfaces

3 interfaces between chains.

A–B · 1731 Å² buried · 48 hydrogen bonds · protein-nucleic
B–C · 375 Å² buried · 31 hydrogen bonds · nucleic-nucleic
A–C · 206 Å² buried · 4 hydrogen bonds · protein-nucleic

Compared structures

5AMR · Structure of the La Crosse Bunyavirus polymerase in complex with the 3' viral RNA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A5HC98
Elsewhere: RCSB PDB 5AMR · PDBe 5AMR · UniProt A5HC98

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